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PIM1, Active(P35-10G)

PIM1, Active(P35-10G)

  • $226.00


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Description :Recombinant full-length human PIM1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_002648

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~62 kDa

Gene Aliases :PIM

Scientific Background :PIM1 is a proto-oncogene that belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, PIM1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others (1). Expression of PIM1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational (2). Expression of PIM1 is mediated through activation of the JAK/STAT pathway.

References :
1. Meeker, TC. et al: Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases. J Cell Biochem. 1987 Oct;35(2):105-12.

2. Friedmann, M. et al: Characterization of the proto-oncogene pim-1: kinase activity and substrate recognition sequence. Arch Biochem Biophys. 1992 Nov 1;298(2):594-601.

Product Sheets (By Lot #) :

S202-2.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases