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Description :Recombinant human PIK3C2G (468-1203) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :BC130277
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :110 kDa
Gene Aliases :MGC163149; PI3K-C2GAMMA
Scientific Background :PIK3C2G belongs to the phosphoinositide 3-kinase (PI3K) family which plays main roles in signaling pathways and involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking (1). PIK3C2G contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs which mediate translocation of proteins to membranes, and may also mediate protein-protein interactions and the N-terminal region of PIK3C2G and the C-terminal C2 domain are required for enzymatic activity (2).
1. Rozycka, M.et.al: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2-gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics 54: 569-574, 1998.
2. Misawa, H. et.al: Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem. Biophys. Res. Commun. 244: 531-539, 1998.
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Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling