PIK3C2B, Active(P24-112BG)

PIK3C2B, Active(P24-112BG)

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Description :Recombinant human PIK3C2B (850-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :850-end

Genbank Number :BC144342

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :98 kDa

Gene Aliases :C2-PI3K

Scientific Background :PIK3C2B or phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta belongs to the phosphoinositide 3-kinase (PI3K) family. PIK3C2B plays a role in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2B is highly expressed in thymus and placenta and it may function in a calcium-independent manner (1). In cell signaling, PIK3C2B stabilizes nucleotide-free Ras and the interaction of Ras and PI3KC2beta mutually inhibits one another activity (2).

References :
1. Brown, R. A.et.al: Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem. Biophys. Res. Commun. 233: 537-544, 1997.

2. Wong KA. et.al: A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation. PLoS One. 2012;7(9):e45360. doi: 10.1371/journal.pone.0045360. Epub 2012 Sep 13.

Product Sheets (By Lot #) :

C2066-3B.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling