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Picropodophyllotoxin(I02-901)

Picropodophyllotoxin(I02-901)

  • $105.00


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Description :IGF1R inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :477-47-4

Molecular Formula :C22H22O8

Appearance :White powder

Melting Point :222-224oC

Molecular Weight :414.4

Purity :>97% (TLC); NMR (Conforms)

Solubilization :Soluble in DMSO (40 mg/ml)

Aliases :(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.

Scientific Background :Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP (1). Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM (1). Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 uM (2). Exhibits antiangiogenic activitiy (3). Attenuates intimal hyperplasia after vascular injury (4). Active in vivo.

References :
1. A Girnita et al. Cancer Res. 2004 64:236

2. A Girnita et al. Clin. Cancer Res. 2006 12:1383

3. E Menu et al. Int. J. Cancer 2007 121:1857

4. A Razuvaev et al. J. Vasc. Surg. 2007 46:108

Molecular Structure :

Product Sheets (By Lot #) :

T2257-71.pdf

Research Areas :Cancer, Metabolic Disorder, AKT/PKB Pathway, ERK/MAPK Pathway, Apoptosis/Autophagy, Cellular Stress, Angiogenesis, Receptor Tyrosine Kinases