PI3K (p120 gamma), Active(P29-102H)
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Description :Recombinant full-length human PI3K (p120 gamma) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Tag :His tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_002649
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :121 kDa
Gene Aliases :p110 gamma: PI3K, PIK3, PI3CG, PI3Kgamma
Scientific Background :PI3K (p120 gamma) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. PI3K (p120 gamma) is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, PI3K (p120 gamma) is thought to play a pivotal role in the regulation of cytotoxicity in NK cells (1). In addition, PI3K (p120 gamma) plays an inhibitory role in inflammatory mediator-induced human vascular smooth muscle cell calcification through regulating alkaline phosphatase expression (2).
1. Jiang, K. et al: Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nature Immun. 1: 419-425, 2000.
2. Patrucco, E.et al: PI3K-gamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118: 375-387, 2004.
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Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling