FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.
Tag :GST tag
Genbank Number :NM_015020
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :~ 56 kDa
Gene Aliases :KIAA0931; PHLPPL
Scientific Background :PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.
1. Brognard, J. et.al: PHLPP and a second isoform, PHLPp2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molec. Cell 25: 917-931, 2007
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Cancer, Phosphatases, PKA/PKC Pathway, Cancer, AKT/PKB Pathway, PKA/PKC Pathway, Phosphatases