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Description :HDAC Inhibitor
CAS Registry Number :1716-12-7
Molecular Formula :C10H11NaO2
Appearance :white powder
Molecular Weight :186.2
Purity :>98% (TLC; 5% CH3OH in CH2Cl2, Rf=0.36)
Solubilization :May be dissolved in DMSO (4 mg/ml); or water (25 mg/ml)
Aliases :4-Phenylbutyric acid, sodium salt
Storage and Stability :Store as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
Scientific Background :Histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Induces differentiation, and apoptosis. Active in vivo.
1. HH Engelhard et al. J. Neuro-Oncol. 1998 37:97
2. IB Appelskog et al. Int. J. Oncol. 2004 24:1419
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Inflammation