Phenylbutyrate NA(H83-904H)

Phenylbutyrate NA(H83-904H)

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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1716-12-7

Molecular Formula :C10H11NaO2

Appearance :white powder

Molecular Weight :186.2

Purity :>98% (TLC; 5% CH3OH in CH2Cl2, Rf=0.36)

Solubilization :May be dissolved in DMSO (4 mg/ml); or water (25 mg/ml)

Aliases :4-Phenylbutyric acid, sodium salt

Storage and Stability :Store as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Induces differentiation, and apoptosis. Active in vivo.

References :
1. HH Engelhard et al. J. Neuro-Oncol. 1998 37:97

2. IB Appelskog et al. Int. J. Oncol. 2004 24:1419

Molecular Structure :

Product Sheets (By Lot #) :

P3320-28.pdf

Research Areas :Cancer, Cell Cycle, Inflammation