Announcement : SignalChem has changed its corporate name from “SignalChem Pharmaceutical Inc.” to “SignalChem Biotech Inc.” effective March 20th 2019.
PFKFB4 Protein (P324-30G)

PFKFB4 Protein (P324-30G)

  • $215.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description : Recombinant human PFKFB4 (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : 2-end

Genbank Number : NM_004567

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~82 kDa

Gene Aliases : (None)

Scientific Background : PFKFB4 (also known as 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4) regulates the steady-state concentration of fructose-2, 6-bisphosphate, a potent activator of a key regulatory enzyme of glycolysis pathway called phosphofructokinase. Isozymes of PFKFB differ in the regions surrounding the catalytic core, which are important for the differential response to allosteric effectors and hormonal signals in different tissues (1). PFKFB4 is highly expressed in brain, heart, liver, muscle, placenta, adipose tissue, ovary, fallopian tubes, and testis (2).

References : 
1. Sakai, A. et.al: Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate,2-kinase/fructose 2,6-bisphosphatase from human placenta. J. Biochem. 119: 506-511, 1996.

2. Manzano, A.et.al: Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. Gene 229: 83-89, 1999.

Product Sheets: (by Lot #):

J677-2.pdf

A1220-2.pdf

G1282-1.pdf

Research Areas : Cancer, Cell Cycle, Metabolic Disorder,