HOLIDAY SHIPPING UPDATE: All delivery service requests will not be processed on Monday, July 1, 2019 as it is Canada Day holiday. Regular delivery schedule will resume the next business day.
PFKFB2 Protein (P322-30G)

PFKFB2 Protein (P322-30G)

  • $215.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description : Recombinant full-length human PFKFB2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : Full length

Genbank Number : NM_006212

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~84 kDa

Gene Aliases : PFK-2/FBPase-2

Scientific Background : PFKFB2 is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. PFKFB2 has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFKFB2 regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle (1). PFKFB2 also functions as a homodimer. PFKFB2 play an important role in the regulation of muscle glycolysis during the first moments of exercise (2).

References : 
1. Hilliker, C. E. et.al: Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Genomics 10: 867-873, 1991.

2. Rovira J. et.al: Upregulation of heart PFK-2/FBPase-2 isozyme in skeletal muscle after persistent contraction. Pflugers Arch. 2012 Apr;463(4):603-13. doi: 10.1007/s00424-011-1068-5.

Product Sheets: (by Lot #):

Z1335-4.pdf

Research Areas : Cancer, Cell Cycle, Metabolic Disorder,