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PDGF(P841-40N)

PDGF(P841-40N)

  • $204.00


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Description :Recombinant human full length PDGF was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :

Expression System:E.coli

Sequence :Full Length

Genbank Number :NP_148983

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of PDGF.

Molecular Weight :~17 kDa

Gene Aliases :PDGF1; PDGFA; PDGF-A

Scientific Background :PDGF is a member of the platelet-derived growth factor family which is mitogenic factors for cells of mesenchymal origin and is characterized by a motif of eight cysteines. PDGF is a cationic glycoprotein consisting of homo- or heterodimers of polypeptide chains A and/or B and a potent mitogen for connective tissue cells and exerts its function by interacting with 2 related receptor tyrosine kinases, PDGFRA and PDGFRB (1). PDGF A and B chain mRNA in mesenchymal-appearing intimal cells and endothelial cells, respectively, of atherosclerotic plaques. Moreover PDGF receptor mRNA was localized predominantly in the plaque intima (2).

References :
1. Bonthron, D. et.al: Platelet-derived growth factors A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. Genomics 13: 257-263, 1992.

2. Wilcox, J. N.et.al: Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J. Clin. Invest. 82: 1134-1143, 1988.

Product Sheets (By Lot #) :

S358-2.pdf

Research Areas :AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases, Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Receptor Tyrosine Kinases