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PDE9A, Active(P97-30G)

PDE9A, Active(P97-30G)

  • $259.00


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Description :Full-length recombinant human PDE9A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_001001567

Specific Activity :Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :PDE Assay

Molecular Weight :~86 kDa

Gene Aliases :FLJ90181; HSPDE9A2

Scientific Background :PDE9A is a member of the phosphodiesterase (PDE) family that catalyzes the hydrolysis of cGMP to the monophosphate and thus plays an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (1). Multiple transcript variants encoding several different isoforms have been found for PDE9A (2). These mRNAs differ in the use of specific combinations of exons located at the 5' end of the gene while the 3' half, encoding the catalytic domain of the protein, always has the same combination of exons. PDE9A has been used in the study of gene- disease association, gene-environment interaction, and pharmacogenomic/toxicogenomic. PDE9A is mainly expressed in spleen, small intestine, and brain.

References :
1. Fisher, D A. et al: Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J. Biol. Chem. 273: 15559-15564, 1998.

2. Soderling, S H. et al: Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 273: 15553-15558, 1998.

Product Sheets (By Lot #) :

R217-2.pdf

R194-1.pdf

Research Areas :Cardiovascular Disease, Inflammation, Phosphodiesterases, Inflammation, Cardiovascular Disease, Phosphodiesterases