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PDE7B, Active(P95-30BG)

PDE7B, Active(P95-30BG)

  • $259.00


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Description :Full-length recombinant human PDE7B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_018945

Specific Activity :Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :PDE Assay

Molecular Weight :~73 kDa

Gene Aliases :MGC88256; bA472E5.1

Scientific Background :PDE7B is a cAMP-specific phosphodiesterase and a member of the cyclic nucleotide phosphodiesterase family that catalyzes the hydrolysis of cAMP to the corresponding 5'-monophosphate and provides a mechanism to downregulate cAMP signaling (1). PDE7B is over-expressed in chronic lymphocytic leukemia and inhibition of PDE7B leads to induction of apoptosis (2). PDE7B has been identified as a candidate gene for measuring treatment response to risperidone and may confer susceptibility to schizophrenia.

References :
1. Hetman, J. M. et.al: Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc. Nat. Acad. Sci. 97: 472-476, 2000.

2. Ikeda, M. et al: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry. 2010 Feb 1;67(3):263-9.

Product Sheets (By Lot #) :

W305-1.pdf

F493-3.pdf

Research Areas :Cardiovascular Disease, Inflammation, Phosphodiesterases, Inflammation, Cardiovascular Disease, Phosphodiesterases