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PD-98059(M02-900)

PD-98059(M02-900)

  • $88.00


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Description :MEK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :167869-21-8

Molecular Formula :C16H13NO3

Appearance :Yellow powder

Melting Point :164-165oC

Molecular Weight :267.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (6 mg/ml)

Aliases :2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 2'-Amino-3'-methoxyflavone

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Inhibitor of mitogen-activated protein kinase kinase (MKK/MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7uM)

References :
1. DR Alessi et al. J. Biol. Chem. 1995 270:27489

2. DT Dudley et al. Proc. Natl. Acad. Sci. USA. 1995 92:7686

Molecular Structure :

Product Sheets (By Lot #) :

T2257-63.pdf

Research Areas :Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases