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PCTK3 (CDK18)/CyclinY, Active(P11-10G)

PCTK3 (CDK18)/CyclinY, Active(P11-10G)

  • $259.00


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Description :Full-length recombinant human PCTK3 (CDK18) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.

Species :Human

Tag :GST tags

Expression System:Sf9 insect cells using baculovirus

Sequence :PCTK3 (CDK18)(Full length) and Cyclin Y (2-end)

Genbank Number :BC011526

Genbank Number 2 :NM_145012

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :PCTK3 (CDK18) ~76 kDa and Cyclin Y ~64 kDa

Gene Aliases :PCTK3: PCTAIRE, PCTAIRE3 CyclinY: CCNY; C10orf9; CBCP1; CCNX; CFP1

Scientific Background :PCTK3 or PCTAIRE protein kinase 3 is a member of the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK3 is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2 (1). PCTK3 is expressed in a variety of human cell lines and tissues (2). Elevation in the protein levels of PCTAIRE 3 in the temporal cortex of Alzheimer's disease relative to control brains, have been observed. It is proposed that PCTAIRE 3 is a paired helical filaments-associated kinase that modulates tau phosphorylation.

References :
1. Meyerson, M.et.al: A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992.

2. Okuda, T.et.al: PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene 7: 2249-2258, 1992

Product Sheets (By Lot #) :

T921-2.pdf

Z1204-1.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases