PCTK2 (CDK17)/CyclinY, Active(P10-10G)

PCTK2 (CDK17)/CyclinY, Active(P10-10G)

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Description :Recombinant full-length human PCTK2 (CDK17) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :PCTK2 (CDK17) (Full length) and Cyclin Y (2-end)

Genbank Number :NM_002595

Genbank Number 2 :NM_145012

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :PCTK2 (CDK17) ~ 88 kDa and Cyclin Y ~ 64 kDa

Gene Aliases :PCTK2 (CDK17): PCTAIRE2; PCTK2 CyclinY: CCNY; C10orf9; CBCP1; CCNX; CFP1

Scientific Background :PCTK2 (CDK17) or cyclin-dependent kinase 17 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK2 has similarity to a rat protein that is thought to play a role in terminally differentiated neurons (1). The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins (2).

References :
1. Hirose T. et.al: PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Eur J Biochem. 1997 Oct 15;249(2):481-8.

2. Meyerson, M.et.al: A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992.

Product Sheets (By Lot #) :

Z1335-1.pdf

Z1168-3.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases