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PCTK1 Protein(P09-35G)

PCTK1 Protein(P09-35G)

  • $215.00


Description :Recombinant human PCTK1(107-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :107-end

Genbank Number :NM_006201

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~62 kDa


Scientific Background :PCTK1 or Pctaire protein kinase 1 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases which play a main role in signal transduction cascades in terminally differentiated cells, in exocytosis and in transport of secretory cargo from the endoplasmic reticulum. PCTK1 is ubiquitously expressed with the highest levels detected in the brain and testis (1). PCTK1 maps distal to the t(X;18) synovial sarcoma breakpoint in Xp11.23. A 420-kb YAC clone positive for PCTK1 also contained the gene coding for ubiquitin-activating enzyme UBE1 previously mapped to Xp11.3. (2). PCTK1 is thought to escape X inactivation.

References :
1. Okuda, T. et.al: PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene 7: 2249-2258, 1992.

2. Knight, J. C. et.al: Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3. Cytogenet. Cell Genet. 71: 155-157, 1995.

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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases