Panobinostat(H83-904G)

Panobinostat(H83-904G)

  • $72.00


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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :404950-80-7

Molecular Formula :C21H23N3O2

Appearance :Off-white powder

Molecular Weight :349.43

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (100 mg/ml); or ethanol (5 mg/ml, warm)

Aliases :(E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl) crylamide; LBH-589

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to one month.

Scientific Background :A potent inhibitor of class I and II HDACs1. Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells2. A potent antimyeloma agent that overcomes drug resistance3.

References :
1. L Geng et al. Cancer Res. 2006 66:11298

2. P George et al. Blood 2005 105:1768

3. P Maiso et al. Cancer Res. 2006 66:5781

Molecular Structure :

Product Sheets (By Lot #) :

P3320-27.pdf

Research Areas :Cancer, Cell Cycle, Inflammation