PAD3, Active (P312-310CG)
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Description : Recombinant full-length human PAD3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : NM_016233
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight : ~97 kDa
Gene Aliases : MGC126307; MGC126308; PADI3; PDI3
Scientific Background : PAD3 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD3 modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. It converts arginine to citrulline in filaggrin at a faster rate than it does in trichohyalin (1). Together with the type I enzyme (PAD1), PAD3 play a role in terminal differentiation of the epidermis.
References :
1. Kanno, T. et.al : Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin. J. Invest. Derm. 115: 813-823, 2000.
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Research Areas : Inflammation,