Announcement : SignalChem has changed its corporate name from “SignalChem Pharmaceutical Inc.” to “SignalChem Biotech Inc.” effective March 20th 2019.
PAD2 Protein (P312-30BG)

PAD2 Protein (P312-30BG)

  • $215.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :  Recombinant full-length mouse PAD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Mouse

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : Full length

Genbank Number : BC049947

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~99 kDa

Gene Aliases : HPAD10; PADI1; PDI; PDI1

Scientific Background : PAD2 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD2 has peptidylarginine deiminase activity against synthetic substrates (1). PAD2 is mainly expressed in the central nervous system, skeletal muscle, spinal cord, cerebrum, cerebellum, and submaxillary gland (2). PAD2 play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.

References : 
1. Ishigami, A. et.al: Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch. Biochem. Biophys. 407: 25-31, 2002.

2. Watanabe, K. et.al: Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase. J. Biol. Chem. 264: 15255-15260, 1989.

Product Sheets: (by Lot #):

I255-1.pdf

F745-1.pdf

Q2307-9.pdf

Research Areas : Inflammation,