PDE2A, Active(P90-30G)

PDE2A, Active(P90-30G)

  • $259.00


Description :Recombinant full-length human PDE2A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_002599

Specific Activity :Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :PDE Assay

Molecular Weight :~130 kDa

Gene Aliases :PDE2A1; PED2A4

Scientific Background :PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5'-GMP. TNFα stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner (1). TNFα-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin (2). Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema.

References :
1. Seybold J, et al: Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability. Blood. 2005 May 1;105(9):3569-76.

2. Diebold I, et al: Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. Circ Res. 2009 May 22;104(10):1169-77.

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Research Areas :Inflammation, Cardiovascular Disease, Phosphodiesterases, Inflammation, Cardiovascular Disease, Phosphodiesterases