Anti-PHLPP1(P71-263R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the PHLPP1 protein
Cited Applications :WB, ELISA
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :PHLPP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PHLPP1
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of PHLPP1 in SW480 cell lysate with PHLPP1 antibody at (A) 1 and (B) 2 ug/mL.
References :
1. Brognard J al: PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol. Metab. 2008; 19:223-30.
2. Gao T al: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 2005; 18:13-24.
3. Brognard J al: PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol. Cell 2007; 25:917-31
4. Andreozzi F al: Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. Diabetologia 2011; 54:1879-87.
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Cancer, Phosphatases, PKA/PKC Pathway, Cancer, AKT/PKB Pathway, PKA/PKC Pathway, Phosphatases