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Description :Full-length recombinant human p63 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_001114980
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~92 kDa
Gene Aliases :TP63; AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
Scientific Background :p63 is the primordial member of the p53 family that acts in a conserved process of monitoring the integrity of the female germline, whereas the functions of p53 are restricted to vertebrate somatic cells for tumor suppression. p63 protein plays an important role in the development and maintenance of stratified epithelial tissues (1). p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis (2). Mutations in p63 are associated with ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3) and split-hand/foot malformation 4 (SHFM4).
1. Yang, A., Schweitzer, R. et.al: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398: 714-718, 1999.
2. Suh, E.-K. et.al: p63 protects the female germ line during meiotic arrest. Nature 444: 624-628, 2006.
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Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, p38 Pathway, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, p38 Pathway, JNK/SAPK Pathway, Apoptosis/Autophagy, Cell Cycle, Cellular Stress