Anti-PLC gamma 1(P40-63R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the PLCγ1 protein
Cited Applications :WB
Cross Reactivity :Western blot human PLCy1
PLCy1 from other species may also be detectable.
Host :Rabbit
Immunogen :Synthetic peptide corresponding to amino acids 769-773 of human PLCγ1
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Representative Western blot with Anti- PLCγ1 (1:1000) using 3 μg, 10 μg and 30 μg of Jurkat cell lysate.(WB)gel.jpg)
Scientific Background :PLCγ1 or phospholipase C gamma 1 plays an important role in the intracellular transduction of message from receptor-mediated tyrosine kinase activation. PLCγ1 catalyzes the formation of two second-messenger molecules inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. PLCγ1 is a major substrate for heparin-binding growth factor 1 activated tyrosine kinase. PLCγ1 inhibits growth factor receptor-mediated invasion of breast and prostate tumor cells and is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE (1).
References :
1. Ye, K. et al: Phospholipase C-gamma-1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 415: 541-544, 2002.
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Research Areas :Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Neurobiology, PKA/PKC Pathway, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, PKA/PKC Pathway