Anti-PTPN11 (SHP2)(P38-63BR)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the PTPN11 protein
Cited Applications :WB, ELISA
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :PTPN11 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human PTPN11.
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of PTPN11 in mouse skeletal muscle tissue lysate with SHP2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Scientific Background :Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2).
References :
1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.
2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993.
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Research Areas :Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Phosphatases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Phosphatases