PFKFB2 Protein (P322-30G)

PFKFB2 Protein (P322-30G)

  • $215.00


Description : Recombinant full-length human PFKFB2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : Full length

Genbank Number : NM_006212

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~84 kDa

Gene Aliases : PFK-2/FBPase-2

Scientific Background : PFKFB2 is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. PFKFB2 has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFKFB2 regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle (1). PFKFB2 also functions as a homodimer. PFKFB2 play an important role in the regulation of muscle glycolysis during the first moments of exercise (2).

References : 
1. Hilliker, C. E. Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Genomics 10: 867-873, 1991.

2. Rovira J. Upregulation of heart PFK-2/FBPase-2 isozyme in skeletal muscle after persistent contraction. Pflugers Arch. 2012 Apr;463(4):603-13. doi: 10.1007/s00424-011-1068-5.

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Research Areas : Cancer, Cell Cycle, Metabolic Disorder,