• $595.00


Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the PIAS4 protein

Cited Applications :WB, ELISA, IF, IHC

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :PIAS4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human PIAS4

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of PIAS4 in rat brain tissue lysate with PIAS4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Sample Data :Immunohistochemistry of PIAS4 in rat brain tissue with PIAS4 antibody at 5 ug/mL.

References :
1. Shuai K et al: Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

2. Nelson V et al: A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-,ediated transactivation but not apoptosis. Apoptosis2001; 6:221-34.

3. Nishida T et al: PIASy controls ubiquitin-dependent proteasomal degradation of Ets-1. Biochem. J.2007; 405:481-8.

4. Galanty Y et al: Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature2009; 462:935-9.

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Research Areas :Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy