Anti-PIAS3(P282-63R)

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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the PIAS3 protein

Cited Applications :WB, ELISA, IF, IHC

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :PIAS3 antibody was raised against a 12 amino acid synthetic peptide near the carboxy terminus of human PIAS3

Purification :Affinity chromatography

Stability :Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of PIAS3 in K562 cell lysate with PIAS3 antibody at 1 ug/mL.

Sample Data :Immunohistochemistry of PIAS3 in human breast carcinoma tissue with PIAS3 antibody at 5 ug/mL.

References :
1. Liu B et al: Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA1998; 95: 10626-31.

2. Shuai K et al: Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

3. Chung CD et al: Specific inhibition of Stat3 signal transduction by PIAS3. Science1997; 278:1803-5.

4. Wang L B et al: Differential PIAS3 expression in human malignancy. Oncol. Rep.2004; 11:1319-24.

5. Zhang Q et al: Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J. Immunol.2002; 168:466-7.

Product Sheets (By Lot #) :

O2361-39.pdf

Research Areas :Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy