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p27KIP1 Protein(C28-30G)

p27KIP1 Protein(C28-30G)

  • $215.00


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Description :Recombinant full-length human p27KIP1 was expressed in E. coli cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :Full Length

Genbank Number :NM_004064

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~52 kDa

Gene Aliases :CDKN1B, CDKN4, MEN1B

Scientific Background :KIP1 (cyclin-dependent kinase inhibitor 1B) is a kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation (1). Many tumorigenic processes modulate cell-cycle progression by regulating the levels of the cyclin-dependent kinase inhibitor KIP1. KIP1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (2). The phosphorylation- and ubiquitination-dependent proteolysis of KIP1 is implicated in control of the G1-S transition in the cell cycle. KIP1 is critical for retinoblastoma protein (Rb)-induced cellular proliferative senescence.

References :
1. Hoyt, M A. et al: Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 1992 118(1):109-120.

2. Carrano,A C. et al: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1999; 1, 193-199

Product Sheets (By Lot #) :

C283-2.pdf

X406-3.pdf

Research Areas :Cancer, Cell Cycle, Cancer, Cell Cycle