Anti-PAK7(P07-63R)
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Description :Rabbit Polyclonal Antibody
Species :
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Expression System:
Sequence :
Specificity :Recognizes the PAK7 protein
Cited Applications :WB, ELISA, ICC, IF
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :PAK7 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK7
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of PAK7 in T24 lysate with PAK7 antibody at (A) 2 and (B) 4 ug/ml.
Sample Data :Immunocytochemistry of PAK7 in K562 cells with PAK7 antibody at 2 ug/ml.
Scientific Background :PAK7 (also known as PAK5) is a novel human PAK family kinase that contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus (1). The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the cytoskeleton and apoptosis. PAK7 like the other Paks has been implicated in the regulation of cell morphology, motility and transformation.
References :1. Pandey, A. et al: Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene. 2002 May 30;21(24):3939-48.
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Research Areas :Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, ERK/MAPK Pathway, Invasion/Metastasis, Ser/Thr Kinases