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OSR1 Protein(O09-34G)

OSR1 Protein(O09-34G)

  • $215.00


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Description :Recombinant full-length human OSR1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_005109

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~86 kDa

Gene Aliases :OXSR1; KIAA1101

Scientific Background :OSR1 is a member of the Ser/Thr family of protein kinases. OSR1 is activated by osmotic stresses and regulates the downstream protein kinase such as PAK1 in order to establish the sensor/signaling modules that initiate the cellular response to environmental stress (1). OSR1 can be phosphorylated by ATM or ATR during DNA damage process (2).

References :
1. Chen W. et al: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J. Biol. Chem. 279:11129-11136(2004).

2. Matsuoka S. et al: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166 (2007).

Product Sheets (By Lot #) :

R316-3.pdf

Research Areas :Cardiovascular Disease, Ser/Thr Kinases, Cardiovascular Disease, Ser/Thr Kinases