OSR1 Protein(O09-34G)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant full-length human OSR1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_005109
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~86 kDa
Gene Aliases :OXSR1; KIAA1101
Scientific Background :OSR1 is a member of the Ser/Thr family of protein kinases. OSR1 is activated by osmotic stresses and regulates the downstream protein kinase such as PAK1 in order to establish the sensor/signaling modules that initiate the cellular response to environmental stress (1). OSR1 can be phosphorylated by ATM or ATR during DNA damage process (2).
References :
1. Chen W. et al: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J. Biol. Chem. 279:11129-11136(2004).
2. Matsuoka S. et al: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166 (2007).
Product Sheets (By Lot #) :
Research Areas :Cardiovascular Disease, Ser/Thr Kinases, Cardiovascular Disease, Ser/Thr Kinases