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  • $61.00


Description :PI3K and mTOR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :915019-65-7

Molecular Formula :C30H23N5O

Appearance :White to off-white powder

Melting Point :285-287oC

Molecular Weight :469.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (1 mg/ml, warm); or DMF (10 mg/ml, warm to 75oC)

Aliases :2-Methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c] quinolin-1-yl] phenyl} propanenitrile

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :A dual PI3K and mTOR kinase inhibitor (1). It inhibits VEGF-induced proliferation and angiogenesis (2). Reverses lapatinib resistance (3). It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis (4). Inhibits the growth of cancer cells with activating PI3K mutations (5). Active in vivo.

References :
1. SM Maira et al. Mol. Cancer Ther. 2008 7:1851

2. CR Schnell et al. Cancer Res. 2008 68:6598

3. PJ Eichhorn et al. Cancer Res. 2008 68:9221

4. R Marone et al. Mol. Cancer Res. 2009 7:601

5. V Serra et al. Cancer Res. 2008 68:8022

Molecular Structure :

Product Sheets (By Lot #) :


Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases