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NPC-15437(P61-900B)

NPC-15437(P61-900B)

  • $61.00


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Description :PKC inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :141774-20-1

Molecular Formula :C25H50N4O2 ∙ 2HCl

Appearance :Light yellow to white powder

Melting Point :N/A

Molecular Weight :511.6

Purity :98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in: water (10 mg/ml)

Aliases :(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl) methyl] hexanamide dihydrochloride hydrate

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19uM) (1,2). It specifically interacts with the C1 domain of PKC (3). Important tool for assessing the role of PKC in various signaling pathways (4). Cell permeable. Active in vivo (4).

References :
1. JP Sullivan et al. Mol. Pharmacol. 1992 41:38

2. JP Sullivan et al. Agents Actions 1991 34:142

3. JP Sullivan et al. FEBS Lett. 1991 285:120

4. K Miyoshi et al. Eur. J. Pharmacol. 2007 562:208

Molecular Structure :

Product Sheets (By Lot #) :

T2257-41.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases