• $595.00


Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the NIK protein

Cited Applications :WB, ELISA

Cross Reactivity :Human

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :NIK antibody was raised against a peptide corresponding to amino acids 931 to 947 of human NIK

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background :NIK is a mitogen-activated protein kinase kinase kinase 14 (MAP3K14), which binds to TRAF2 and stimulates NF-kappaB activity. NIK shares sequence similarity with several other MAPKK kinases and participates in NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. (1) NIK is expressed in primary human cells and in inflamed rheumatoid arthritis tissue and plays a selective role in signaling by the lymphotoxin-beta receptor (2). NIK is a therapeutic target in the immune and bone-destructive components of inflammatory arthritis.

References :
1. Smith, C. NF-kappa-B-inducing kinase is dispensable for activation of NF-kappa-B in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappa-B in primary human fibroblasts. J. Immun. 167: 5895-5903, 2001.

2. Yin, L. Defective lymphotoxin-beta receptor-induced NF-kappa-B transcriptional activity in NIK-deficient mice. Science 291: 2162-2165, 2001.

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Research Areas :Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases, Cancer, Inflammation, ERK/MAPK Pathway