Anti-TRKA(N16-63R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the TRKA protein
Cited Applications :IF
Cross Reactivity :Human
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :The antibody was produced against synthesized non-phosphopeptide derived from human TRKA around the phosphorylation site of tyrosine791 (P-V-YP-L-D).
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Immunofluorescnece staining of methanol-fixed HeLa cells using Anti-TRKA.
Scientific Background :TRKA is a member of the TRK proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140TRK on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).
References :
1. Kaplan, D R. et al: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8.
2. Boissiere, F. et al: Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):219-23.
Product Sheets (By Lot #) :
Research Areas :Neurobiology, Receptor Tyrosine Kinases, Neurobiology, Receptor Tyrosine Kinases