NIM1, Active(N14-10G)
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Description :Recombinant full-length human NIM1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_153361
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~74 kDa
Gene Aliases :MGC42105, NIM1K
Scientific Background :NIM1 belongs to CAMK Ser/Thr protein kinase family. Unlike to other AMPK-related kinases, NIM1 cannot be phosphorylated and activated by LKB1 (1). Two somatic mutations (P333S and P411T) were found in lung neuroendocrine carcinoma and lung large cell carcinoma samples (2).
References :
1. Jaleel M. et.al: Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett. 579:1417-1423(2005).
2. Greenman C. et.al: Patterns of somatic mutation in human cancer genomes. Nature 446:153-158(2007).
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases