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MS-275 (Entinostat)(H83-904E)

MS-275 (Entinostat)(H83-904E)

  • $83.00


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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :209783-80-2

Molecular Formula :C21H20N4O3

Appearance :Pale yellow powder

Melting Point :159-160oC

Molecular Weight :376.41

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (25 mg/ml, warm)

Aliases :Pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate; Entinostat

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 1 week.

Scientific Background :A potent and selective non-hydroxamate HDAC inhibitor. Considered to be a class I selective inhibitor but displays some selectivity amongst class I members: HDAC1 (IC50 = 0.3 uM); HDAC3 (IC50 = 8 uM) with no inhibition of HDAC8 (at >100 uM)1. Induces hyperacetylation of nuclear histones in tumor cells resulting in inhibition of proliferation of a variety of human tumor cell lines2. Protects p53-deficient mice against ischemic injury3. Supresses the p38 MAP kinase pathway in rheumatoid arthritic synovial fibroblasts4. Active in vivo.

References :
1. E Hu et al. J. Pharmacol. Exp. Ther. 2003 307:720

2. A Saito et al. Proc. Natl. Acad. Sci. USA 1999 96:4592

3. SP Murphy et al. J. Neurochem. 2013 Oct 21 epub

4. QY Choo et al. Molecules 2013 18:14085

Molecular Structure :

Product Sheets (By Lot #) :

P3320-24.pdf

Research Areas :Cancer, Cell Cycle, Inflammation