MRCK beta, Active(C28-11G)

MRCK beta, Active(C28-11G)

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Description :Recombinant human MRCKbeta (1-473) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-473

Genbank Number :NM_006035

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~73 kDa

Gene Aliases :CDC42BPB, KIAA1124

Scientific Background :Myotonic Dystrophy Kinase-Related cdc42-binding kinase beta (MRCKβ) belongs to the DMPK subfamily (1). The myotonic dystrophy kinase-related kinases and myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) are effectors of RhoA and Cdc42, respectively, where they are involved in actin cytoskeletal reorganization and neurite outgrowth (2). Effects of the repeat expansion on the DMPK gene may be responsible for muscle and heart features of Myotonic Dystrophy.

References :
1. Lam. L T. et al: Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. Hum. Mol. Genet. 2000; 9(14): 2167-73.

2. Tan, I. et al: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. J. Biol Chem. 2001; 276(24):21209-16.

Product Sheets (By Lot #) :

C103-1.pdf

Research Areas :Cancer, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases