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MRCK alpha, Active(C27-11G)

MRCK alpha, Active(C27-11G)

  • $226.00


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Description :Recombinant human MRCKalpha (1-473) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-473

Genbank Number :NM_003607

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight : ~73 kDa

Gene Aliases :CDC42BPA, MRCK, PK428, FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738

Scientific Background :Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase α (MRCKα) is a Cdc42/Rac/Rho interactive/binding serine/threonine kinase with multiple functional domains (1). MRCK are effectors of RhoA and Cdc42, respectively, for actin reorganization. MRCKα is a critical regulator of signal transduction pathways in eukaryotic cells that are known principally for their role in regulating the cytoskeleton, and they do so by recruiting a variety of downstream effector proteins (2).

References :
1. Ivan, T. et al: Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase α reveals multiple alternative splicing and functional diversity. Gene; 2003; 304:107-115.

2. Ivan, T. et al: Phosphorylation of a Novel Myosin Binding Subunit of Protein Phosphatase 1 Reveals a Conserved Mechanism in the Regulation of Actin Cytoskeleton. J. Biol. Chem., 2001: 276 (24): 21209-21216.

Product Sheets (By Lot #) :

N331-2.pdf

Research Areas :Cancer, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases