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Description :Recombinant human Mortalin (47-end) protein was expressed in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :NM_004134
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~97 kDa
Gene Aliases :HSPA9; CSA; GRP75; HSPA9B; MGC4500; MOT; mot-2; MOT2; MTHSP75; PBP74
Scientific Background :Mortalin is a mitochondrial chaperone and a member of the heat shock protein 70 family that is constitutively expressed in cells. Mortalin plays a central role in mitochondrial biogenesis through its capacity to direct the import of nuclear-encoded proteins into the mitochondria. Mortalin plays a role in the control of cell proliferation and elevated levels of mortalin have correlated with malignant transformation and poor cancer prognosis. Mortalin can support cancer cell resistance to complement-dependent cytotoxicity (1). Mortalin expression was decreased in the mitochondrial fraction of neurons from the substantia nigra of Parkinson disease patients (2).
1. Pilzer, D. et al: Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. Int J Cancer. 2010 Mar 15;126(6):1428-35.
2. De Mena, L. et al: Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease. J Neural Transm. 2009 Oct;116(10):1289-93.
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Research Areas :Apoptosis/Autophagy, Cancer, Cancer, Apoptosis/Autophagy