HOLIDAY SHIPPING UPDATE: All delivery service requests will not be processed on Monday, July 1, 2019 as it is Canada Day holiday. Regular delivery schedule will resume the next business day.
MLL2 (KMT2D), Active(M342-381G)

MLL2 (KMT2D), Active(M342-381G)

  • $259.00


Description :Recombinant human MLL2 (5317-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :5317-end

Genbank Number :NM_003482

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :51 kDa

Gene Aliases :MLL2; MLL4; KMT2D; AAD10; ALR; CAGL114; KABUK1; KMS; TNRC21

Scientific Background :Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors.

References :
1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15(6):334-46. 2015.

2. Huether R. et al: The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nat Commun 5: 3630. 2014.

Product Sheets (By Lot #) :


Research Areas :Cancer