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MLL1 (KMT2A), Active(M341-381G)

MLL1 (KMT2A), Active(M341-381G)

  • $259.00


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Description :Recombinant human MLL1 (3738-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :3738-end

Genbank Number :NM_005933

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :52 kDa

Gene Aliases :MLL1; KMT2A; ALL-1; CXXC7; HRX; HTRX1; MLL; MLL-AF9; MLL/GAS7; MLL1A; TET1-MLL; TRX1; WDSTS

Scientific Background :Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL.

References :
1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15(6): 334-46. 2015.

2. http://www.uniprot.org/uniprot/Q

Product Sheets (By Lot #) :

L2041-6.pdf

Research Areas :Cancer