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MLK4, Active(M48-11G)

MLK4, Active(M48-11G)

  • $226.00


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Description :Recombinant human MLK4 (114-420) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :114-420

Genbank Number :NM_032435

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~61 kDa

Gene Aliases :dJ862P8.3; KIAA1804; RP5-862P8.2; MAP3K21

Scientific Background :MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas (1). MLK4 is a negative regulator of TLR4 (2).

References :
1. Nagase, T.et.al;: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001.

2. Seit-Nebi, A. et.al: MLK4 has negative effect on TLR4 signaling. Cell. Molec. Immun. 9: 27-33, 2012.

Product Sheets (By Lot #) :

Y826-3.pdf

Y982-2.pdf

Z1264-2.pdf

E3153-5.pdf

Research Areas :Apoptosis/Autophagy, Cell Cycle, JNK/SAPK Pathway, Ser/Thr Kinases, JNK/SAPK Pathway, Apoptosis/Autophagy, Cell Cycle, Ser/Thr Kinases