FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :JMJD2 Inhibitor
CAS Registry Number :1222800-79-4
Molecular Formula :C21H23N3O2
Appearance :Light brown-colored powder
Molecular Weight :349.43
Purity :>98% (TLC)
Solubilization :Soluble in DMSO (20 mg/ml, warm); or ethanol (6 mg/ml, warm)
Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 1 month.
Scientific Background :Inhibits JMJD2 histone demethylases. (JMJD2 IC50=920 nM) Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 uM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons1. Cell permeable.
1. Yu Liang et al. Sci. Transl. Med. 2013 5:167ra5
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Inflammation