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ML-324(J48-904E)

  • $105.00


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Description :JMJD2 Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1222800-79-4

Molecular Formula :C21H23N3O2

Appearance :Light brown-colored powder

Molecular Weight :349.43

Purity :>98% (TLC)

Solubilization :Soluble in DMSO (20 mg/ml, warm); or ethanol (6 mg/ml, warm)

Aliases :N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 1 month.

Scientific Background :Inhibits JMJD2 histone demethylases. (JMJD2 IC50=920 nM) Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 uM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons1. Cell permeable.

References :
1. Yu Liang et al. Sci. Transl. Med. 2013 5:167ra5

Molecular Structure :

Product Sheets (By Lot #) :

P3320-23.pdf

Research Areas :Cancer, Cell Cycle, Inflammation