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MINK1, Active(M53-11G)

MINK1, Active(M53-11G)

  • $226.00


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Description :Recombinant human MINK1 (1-320) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-320

Genbank Number :NM_015716

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~61 kDa

Gene Aliases :B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKB

Scientific Background :MINK1 is a member of the germinal center family of kinases that are homologous to the Ste20 family and regulate a wide variety of cellular processes, including cell morphology, cytoskeletal rearrangement, and survival (1). Overexpression of kinase-dead mutants of MINK1 leads to enhanced cell spreading, actin stress fiber formation, adhesion to extracellular matrix and decreased cell motility and invasion. MINK is activated after Ras induction via a mechanism involving reactive oxygen species and mediates stimulation of p38 MAPK downstream of the Raf/ERK pathway (2).

References :
1. Hu, Y. et al: Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J Biol Chem. 2004 Dec 24;279(52):54387-97.

2. Nicke, B. et al: Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell. 2005 Dec 9;20(5):673-85

Product Sheets (By Lot #) :

J593-2.pdf

B1965-7.pdf

Research Areas :Cancer, Neurobiology, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Neurobiology, Invasion/Metastasis, Ser/Thr Kinases