Announcement : SignalChem has changed its corporate name from “SignalChem Pharmaceutical Inc.” to “SignalChem Biotech Inc.” effective March 20th 2019.
MHY-1485 (F17-901B)

MHY-1485 (F17-901B)

  • $61.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :  mTOR activator

CAS Registry Number: 326914-06-1

Molecular Formula : C17H21N7O4

Appearance : Off white powder

Molecular Weight : 387.40

Purity :  >98% (TLC); NMR (conforms)

Solubilization : May be dissolved in DMSO (20 mg/ml); or DMF (10 mg/ml)

Aliases : 4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

Storage and Stability : Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to two months.

Scientific Background : mTOR activator suppresses autophagy by inhibiting the fusion of autophagosomes with lysosomes leading to the accumulation of enlarged autophagosomes1. Increases ovarian follicle development2. Displays cellular protective effects from cytotoxic doses of dexamethasone3 or UV radiation4. A useful tool for probing the cellular role of mTOR5. Cell permeable.

References : 
1. YJ Choy et al. PLoS One 2012 7(8):e43418
2. Y Cheng et al. PLoS One 2015 10(2):e0117769
3. S Zhao et al. Biochem. Biophys. Res. Commun. 2016 481:212
4. B Yang et al. Oncotarget 2017 481:212 Jan 4, Epub
5. C Li and HM Siragy Am. J. Physiol. Endocrinol. Metab. 2015 309:E302

Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Product Sheets (By Lot #):

D3370-17.pdf

Research Areas: AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder,