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METTL3 Protein(M323-30G)

METTL3 Protein(M323-30G)

  • $314.00


Description :Recombinant full-length human METTL3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_019852

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Enzyme Function Tests

Molecular Weight :~100 kDa

Gene Aliases :IME4; M6A; MT-A70; Spo8

Scientific Background :N6-adenosine-methyltransferase 70 kDa subunit (MT-A70 or METTL3) belongs to the methyltransferase superfamily that methylates adenosine residues of some RNAs. It acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing.

References :
1. http://www.uniprot.org/uniprot/Q86U44

2. Liu J, et al: METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 10(2):93-5, 2014.

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Research Areas :Neurobiology