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Description :Recombinant full-length human METTL3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_019852
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Function Tests
Molecular Weight :~100 kDa
Gene Aliases :IME4; M6A; MT-A70; Spo8
Scientific Background :N6-adenosine-methyltransferase 70 kDa subunit (MT-A70 or METTL3) belongs to the methyltransferase superfamily that methylates adenosine residues of some RNAs. It acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing.
2. Liu J, et al: METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 10(2):93-5, 2014.
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Research Areas :Neurobiology