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Description :Recombinant full-length human METTL1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_005371
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Function Tests
Molecular Weight :~57 kDa
Gene Aliases :C12orf1; TRM8; TRMT8; YDL201w
Scientific Background :Methyltransferase Like 1 (METTL1) catalyzes the formation of N (7)-methylguanine at position 46 (m7G46) in tRNA. It belongs to the methyltransferase superfamily. METTL1 is involved in the pathway N (7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.
2. Maj MC, et al: Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation. J Clin Endocrinol Metab. 90(7):4101-7, 2005.
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Research Areas :Cancer, Neurobiology