MEK7, Active(M08-10G)

MEK7, Active(M08-10G)

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Description :Recombinant full-length human MEK7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :BC038295

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~78 kDa

Gene Aliases :MAP2K7; MKK7; JNKK2; MAPKK7; PRKMK7; SKK4

Scientific Background :Mitogen-activated protein kinase 7 (MKK7 or MEK7) is a dual-specificity protein kinase of the STE7 family. Directly phosphorylates the Thr-Pro-Tyr motif located in the activation loop of JNK1/2 and activate the kinases in response to environmental stress, pro-inflammatory cytokines or developmental cues. The activation of MKK7 is mediated by various MAPKKKs, including mixed lineage protein kinases (MLKs) and MAPK/ERK kinase (MEK) kinase (MEKK1).

References :
1. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 103(2):239-52, 2000.

2. Chang L, et al: Mammalian MAP kinase signalling cascades. Nature. 410(6824):37-40, 2001.

3. Asaoka Y, et al: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J Biochem. 48(4):393-401, 2010.

Product Sheets (By Lot #) :

U1702-9.pdf

C2151-6.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases