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MEK4 (MAP2K4), Active(M05-10G)

MEK4 (MAP2K4), Active(M05-10G)

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Description :Recombinant full-length human MEK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_003010

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~71 kDa

Gene Aliases :MAP2K4, JNKK1, MAPKK4, MKK4, PRKMK4, SKK-1, SEK1

Scientific Background :Mitogen-activated protein kinase kinase 4 (MEK4 or MKK4) is dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MKK4 preferentially phosphorylates the tyrosine residue of JNKs. Mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MKK4 is important for carcinogenesis, a loss-off-function mutation in MKK4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MKK4.

References :
1. Lin A, et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 268: 286-90, 1995.

2. Wang L, et al. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors. Oncogene. 23:5978-85, 2004.

Product Sheets (By Lot #) :

U1666-5.pdf

E3019-6.pdf

Research Areas :Cardiovascular Disease, Cancer, Apoptosis/Autophagy, Ser/Thr Kinases, Neurobiology, Invasion/Metastasis, ERK/MAPK Pathway, Angiogenesis